The oral mucosa is vascularized whereby absorbed drugs get direct access to the systemic circulation without first pass metabolism. Taking this advantage the present work is to formulate mouth dissolving film of telmisartan for enhanced bioavailability. Drug and excipients studies were conducted using FTIR. Oral films of telmisartan were formulated using HPMC K4M as a film forming agent and propylene glycol as plasticizer. The solvent casting method was used for the preparation of films. Telmisartan oral film was evaluated for folding endurance, thickness, weight variation test, surface pH, content uniformity, dissolving time and in-vitro dissolution. No drugââ?¬â??excipients interaction was observed. The characterization studies depict the purity of drug and all the excipients used in the formulation. The IR spectrum of mixture of telmisartan with all other excipients does not show any changes which indicate its compatibility with other excipients. From the results, it can be concluded that the fast dissolving oral film of telmisartan showed fast disintegration, dissolution of drug in salivary pH. Thus the prepared fast dissolving films of telmisartan could be a better alternative for achieving rapid oral bioavailability.
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